MxA suppresses TAK1-IKK α/β-NF-κB mediated inflammatory cytokine production to facilitate Mycobacterium tuberculosis infection

Mycobacterium tuberculosis (Mtb) is an aggressive intracellular pathogen and causes tuberculosis (TB). In 2018, 10.0 million people had TB after Mtb infection and 1.4 million of them were died of the diseases [1]. Both innate and adaptive immune cells such as macrophages (M ϕs) and T lymphocytes, play important roles in defensing against mycobacterial infection. However, Mtb can evade the host immune response to tackle the survival strategy [2]. Therefore, in-depth study to identify the host factors involved in the pathogenesis of TB is needed to develop host-directed therapies for eradicating Mtb infection and preventing drug resistance.

Source: Journal of Infection - May 19, 2020 Category: Infectious Diseases Authors: Xinying Zhou, Lijie Zhang, Linmiao Lie, Zelin Zhang, Bo Zhu, Jiahui Yang, Yuchi Gao, Pengfei Li, Yingqi Huang, Hui Xu, Yanfen Li, Xialin Du, Chaoying Zhou, Shengfeng Hu, Qian Wen, Xiao-Ping Zhong, Li Ma Source Type: research