Netherton Syndrome: Insights into Pathogenesis and Clinical Implications

Netherton syndrome (NS) is a rare skin disorder involving the skin, hair, and immune system. Pathological manifestations are due to unopposed kallikrein peptidase activity because of a SPINK5 gene deficiency. In their article, Gouin et  al. explore the role of kallikrein 14 in the stratum granulosum, defining it as an important player implicated in the pathogenesis of NS hair shaft anomalies.

Source: Journal of Investigative Dermatology - May 20, 2020 Category: Dermatology Authors: Elena Chiticariu, Daniel Hohl Tags: Commentary Source Type: research