Loss of Methylation Modification Marks the Presence of Psoriasis

The reversibility of epigenetic alterations makes them the attractive targets for therapeutic discovery; however, their potential remains untapped owing to a lack of mechanistic understanding, particularly for inflammatory skin disorders. Here, Li and colleagues begin to fill these gaps by identifying the loss of the DNA hydroxymethylation mark 5-hmC in psoriasis and presenting compelling evidence for its potential contribution to disease manifestations.

Source: Journal of Investigative Dermatology - May 20, 2020 Category: Dermatology Authors: Brian C. Capell, John T. Seykora Tags: Commentary Source Type: research