Cancers, Vol. 12, Pages 1294: A Novel Role of Interleukin 13 Receptor alpha2 in Perineural Invasion and its Association with Poor Prognosis of Patients with Pancreatic Ductal Adenocarcinoma

Cancers, Vol. 12, Pages 1294: A Novel Role of Interleukin 13 Receptor alpha2 in Perineural Invasion and its Association with Poor Prognosis of Patients with Pancreatic Ductal Adenocarcinoma Cancers doi: 10.3390/cancers12051294 Authors: Toshio Fujisawa Takeshi Shimamura Kaku Goto Ryo Nakagawa Ryosuke Muroyama Yoshinori Ino Hajime Horiuchi Itaru Endo Shin Maeda Yasushi Harihara Atsushi Nakajima Nobuyuki Matsuhashi Naoya Kato Hiroyuki Isayama Ankit Puri Akiko Suzuki Ian Bellayr Pamela Leland Bharat H. Joshi Raj K. Puri Perineural invasion (PNI) is one of the major pathological characteristics of pancreatic ductal adeno-carcinoma (PDAC), which is mediated by invading cancer cells into nerve cells. Herein, we identify the overexpression of Interleukin-13 Receptor alpha2 (IL-13Rα2) in the PNI from 236 PDAC samples by studying its expression at the protein levels by immunohistochemistry (IHC) and the RNA level by in situ hybridization (ISH). We observe that ≥75% samples overexpressed IL-13Rα2 by IHC and ISH in grade 2 and 3 tumors, while ≥64% stage II and III tumors overexpressed IL-13Rα2 (≥2+). Interestingly, ≥36 % peripancreatic neural plexus (PL) and ≥70% nerve endings (Ne) among PNI in PDAC samples showed higher levels of IL-13Rα2 (≥2+). IL-13Rα2 +ve PL and Ne subjects survived significantly less tha...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research