Circulating inflammation-related factors are correlated with systemic redox status in IgA nephropathy; a case-control study.

CONCLUSIONS: Patients with IGAN had disturbed redox status. Several circulating inflammation-related factors were elevated, suggesting activation of the non-canonical NF-kB pathway. There was a positive relationship between systemic redox status and the level of inflammation-related factors, partially independent of GFR. The present findings raise the question of whether circulating oxidized free Cys and/or nitrate may be employed as prognostic biomarkers for IGAN in the future.
PMID: 32428564 [PubMed - as supplied by publisher]

Source: Free Radical Biology and Medicine - May 15, 2020 Category: Biology Authors: Apeland T, Mansoor MA, Furriol J, Ushakova A, Jonsson G, Stangeland K, Marti HP Tags: Free Radic Biol Med Source Type: research