Sirtuin 3 is required for the protective effect of Resveratrol on Manganese ‐induced disruption of mitochondrial biogenesis in primary cultured neurons

In conclusion, our findings demo nstrated that RSV could ameliorate Mn‐induced neuronal injury and mitochondrial dysfunction in primary cultured neurons through activating the SIRT1/ PGC‐1α signaling pathway, and that SIRT3 is required for promoting mitochondrial biogenesis and attenuating Mn‐induced mitochondrial dysfunctio n.

Source: Journal of Neurochemistry - May 18, 2020 Category: Neuroscience Authors: Qian Sun, Run ‐Run Kang, Kai‐Ge Chen, Kuan Liu, Zhuo Ma, Chang Liu, Yu Deng, Wei Liu, Bin Xu Tags: ORIGINAL ARTICLE Source Type: research