Adaptor protein RapZ activates endoribonuclease RNase E by protein-protein interaction to cleave a small regulatory RNA.
In conclusion, RapZ boosts RNase E activity through interaction with its catalytic domain, which represents a novel mechanism of RNase E activation. In contrast, RNA-binding has a recruiting role, increasing the likelihood that productive RapZ/GlmZ/RNase E complexes form.
PMID: 32424019 [PubMed - as supplied by publisher]
Source: RNA - Category: Genetics & Stem Cells Authors: Durica-Mitic S, Göpel Y, Amman F, Görke B Tags: RNA Source Type: research