Effects of anti-T2 biologic treatment on lung ventilation evaluated by MRI in adults with prednisone-dependent asthma.

Effects of anti-T2 biologic treatment on lung ventilation evaluated by MRI in adults with prednisone-dependent asthma.
Chest. 2020 May 16;:
Authors: Svenningsen S, Eddy RL, Kjarsgaard M, Parraga G, Nair P
Abstract
BACKGROUND: The functional consequence of airway obstruction in asthma can be regionally measured using inhaled gas magnetic resonance imaging (MRI). Ventilation defects visualized by MRI persist post-bronchodilator in severe asthmatics with uncontrolled sputum eosinophilia and may be due to eosinophil driven airway pathology that is responsive to "anti-T2" therapy.
RESEARCH QUESTION: Do anti-T2 therapies that clear eosinophils from the airway lumen decrease ventilation defects, measured by inhaled gas MRI, in adults with prednisone-dependent asthma?
STUDY DESIGN: and Methods: Inhaled hyperpolarized gas MRI was performed pre- and post-bronchodilator in 10 prednisone-dependent asthmatics with uncontrolled eosinophilic bronchitis (sputum eosinophils ≥3%) at baseline and 558 [100-995] days later when their eosinophilic bronchitis had been controlled (sputum eosinophils <3%) by additional anti-T2 therapy. The effect of anti-T2 therapy on ventilation defects, quantified as the MRI ventilation-defect-percent (VDP), was evaluated pre- and post-bronchodilator for all patients and compared between patients dichotomized based on the median percentage of sputum eosinophils at baseline (15.8%).
RESULTS: MRI...

Source: Chest - May 15, 2020 Category: Respiratory Medicine Authors: Svenningsen S, Eddy RL, Kjarsgaard M, Parraga G, Nair P Tags: Chest Source Type: research