Baseline Characteristics and Progression of a Spectrum of Interstitial Lung Abnormalities and Disease in Rheumatoid Arthritis.

Baseline Characteristics and Progression of a Spectrum of Interstitial Lung Abnormalities and Disease in Rheumatoid Arthritis. Chest. 2020 May 16;: Authors: Kawano-Dourado L, Doyle TJ, Bonfiglioli K, Sawamura MVY, Nakagawa RH, Arimura FE, Lee HJ, Arrais de Souza Rangel D, Bueno C, Carvalho CRR, Sabbag ML, Molina C, Rosas IO, Kairalla RA Abstract BACKGROUND: Interstitial lung abnormalities (ILA) and interstitial lung disease (ILD) are seen in up to 60% of individuals with rheumatoid arthritis (RA), some of which will progress to have a significant impact on morbidity and mortality. Better characterization of progressive interstitial changes and identification of risk factors associated with progression may enable earlier intervention and improved outcomes. RESEARCH QUESTION: what are baseline characteristics associated with RA-ILD progression? STUDY DESIGN: and Methods: Retrospective study where all clinically-indicated computed tomography (CT) chest scans in adult RA subjects from 2014-16 were evaluated for interstitial changes and further subdivided into ILA and ILD based on clinical record review. Progression was determined visually and subsequently semi-quantified. RESULTS: Those with a spectrum of interstitial changes (64 out of 293) were older male smokers and less likely on biologics/small molecule disease-modifying anti-rheumatic drugs. Of 44% with ILA, 46% had chest CTs performed for non-pulmonary indi...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research