Detection of hepatocyte growth factor in oral rinses using water for possible periodontal diagnosis.

Detection of hepatocyte growth factor in oral rinses using water for possible periodontal diagnosis.
J Oral Sci. 2020 May 15;:
Authors: Suzuki S, Aoki A, Katagiri S, Maekawa S, Ejiri K, Kong S, Nagata M, Yamaguchi Y, Ohshima M, Izumi Y
Abstract
The aim of this study is to analyze the relationship between Hepatocyte Growth Factor (HGF) levels in oral rinses using water and clinical parameters of periodontitis; and furthermore, to evaluate the potential of a prototype HGF immunochromatographic paper test strip (HGF-TS) for screening of periodontitis, in comparison with a commercially-available occult blood (hemoglobin) test strip (Hb-TS). Clinical periodontal parameters were recorded, and oral rinses were collected, from 125 subjects. Then, the presence of HGF, and hemoglobin (Hb), in each sample was detected using a prototype HGF-TS and an Hb-TS. In addition, the concentrations of HGF and Hb were also determined in each sample is necessary HGF concentrations in oral rinses showed significant correlations with clinical parameters of periodontitis. The positive rate and read value on HGF-TS showed significantly high values in cases of severe periodontitis compared to healthy subjects. Hb-TS showed generally higher positive rates than HGF-TS; however, it showed false positive results in healthy subjects. The concentration of HGF in oral rinses showed close association with the severity of periodontitis, suggesting that the prototype HGF-...

Source: Journal of oral science - May 20, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research