Johnson & Johnson to End Talc-Based Baby Powder Sales in North America

The company has faced thousands of lawsuits from cancer patients who claim that its talc was contaminated with asbestos, a known carcinogen, and that the company knew of the risks.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Food and Drug Administration Johnson & Recalls and Bans of Products Source Type: news

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Authors: Kowalik A, Wincewicz A, Zięba S, Baran W, Kopczyński J, Koda M, Sulkowski S, Goźdź S Abstract Molecular next gene sequencing was used to evaluate mutations in 409 common mutated cancer-related genes in malignant mesothelioma of tunica vaginalis testis (MMTVT) of 81-year-old man. Multifocal papillary-solid areas contained necrosis among highly cellular fields with multiple mitoses. It was positive for WT1, CKAE1/AE3, calretinin, CK7 with negativity for CK5, PSA, TTF-1. Following mutations were revealed in PARP1 (NM_001618: c.2285TG, p.I49M) and two sorts of mutations in structure of KMT2C gene (NM_17060...
Source: Polish Journal of Pathology - Category: Pathology Tags: Pol J Pathol Source Type: research
ConclusionsOur observations suggest that a molecular ‐guided treatment approach is feasible for the management of advanced malignant mesothelioma. Our analysis revealed gender specific differences in PDGFRα expression that should be further evaluated in clinical trials.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
This article is protected by copyright. All rights reserved. PMID: 32437065 [PubMed - as supplied by publisher]
Source: Cell Biology International - Category: Cytology Authors: Tags: Cell Biol Int Source Type: research
Malignant pleural mesothelioma (MPM) is a rare and aggressive malignant tumor primarily affecting the pleura with approximately 80 % of cases resulting from occupational or environmental asbestos exposure [1 –4]. The MPM incidence is suspected to increase in the future in many countries in which asbestos either has not yet been banned or is still largely used. The prognosis of MPM is very poor, with a median survival time between 12 and 18 months and a 5-year survival rate of
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Johnson &Johnson announced Tuesday that it will stop selling its iconic, talc-based baby powder, the target of thousands of lawsuits claiming that its talc was contaminated with asbestos, which led to cancers such as mesothelioma and ovarian cancer. The company said the stoppage is only in the United States and Canada, citing a decline in consumer demand and “misinformation” about the safety of the product. “Demand for talc-based Johnson’s Baby Powder in North America has been declining due in large part to changes in consumer habits and fueled by misinformation around the safety of the product ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Johnson &Johnson discontinued its legacy talc-based baby-powder products in the U.S. and Canada after thousands of suits alleging asbestos contamination led to a decline in sales. The health-care giant said Tuesday it had stopped shipping hundreds of talc-based items in the U.S. and Canada after coming to a “commercial decision” to discontinue them. J&J will wind down sales in those markets over the coming months, said Kathleen Widmer, chairman of the company’s North America consumer unit. All existing inventory will continue to be sold through retailers until supplies run out, she said. J&J first beg...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Companies News Desk wire Source Type: news
(ECOG-ACRIN Cancer Research Group) PrECOG, LLC is reporting on its single-arm phase two study PrE0505 for the initial treatment of patients with malignant pleural mesothelioma. The trial evaluated adding durvalumab, an immune checkpoint antibody targeting PD-L1, to pemetrexed and cisplatin chemotherapy in 55 patients of any histologic subtype. The study met its primary endpoint with a median overall survival of 20.4 months as compared to the historical control of 12.1 months. The combination was well-tolerated with no unexpected toxicities.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Pemetrexed is widely used as an anti-folate cytostatic agent for the treatment of non-small cell lung cancer (NSCLC), mesothelioma and thymoma. [1 –5] Dependent on treatment indication, therapy generally exists of four cycles of induction therapy with pemetrexed and a platinum-agent, which can be combined with the recently approved programmed death-ligand 1 (PD-L1) targeting monoclonal antibody pembrolizumab [6]. Pemetrexed - and, if applica ble, pembrolizumab - can be continued as maintenance treatment following the induction period [3,6].
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
The Scientific Analytical Institute in Greensboro, North Carolina, recently uncovered asbestos-contaminated talc in two new eyeshadow makeup products sold online on sites like Amazon and eBay. Its findings were the latest example in a growing list of talc-based cosmetic products found to contain toxic asbestos. Scientific Analytical Institute found asbestos fibers in 40% of the shades tested in Jmkcoz 120 Colors Eyeshadow Palette. It found traces of asbestos in 20% of the shades tested in the Beauty Glazed Gorgeous Me Eye Shadow Tray Palette. The results were released by the Environmental Working Group in Washington, D.C.,...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
In conclusion, our study has identified that acidic mesothelioma milieu drives DC dysfunction and altered T cell response through pharmacologically reversible TGF-β2-dependent mechanisms.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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