COMMENTARY: A Quick Summary of the COVID-19 Literature So Far

Who can keep up with the explosion of papers on SARS-CoV-2? Two Boston-based HIV Fellows have done four biweekly deep dives into the COVID-19 literature. Read their highlights to date.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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TACB Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on viral polyprotein processing, catalysed by the main proteinase (Mpro). The solution of the SARS-CoV-2 Mpro structure allowed the investigation of potential inhibitors. This work aims to provide first evidences of the applicability of commercially approved drugs to treat coronavirus disease-19 (COVID-19). We screened 4,334 compounds to found potential inhibitors of SARS-CoV-2 replication using an in silico approach. Our results evidenced the potential use of coagulation modifiers in COVID-19 treatment due to the structu...
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
This article is to examine and summarize the 2 opposing viewpoints and provide guideline recommendations to support the use or discontinuation of ACE inhibitors and ARBs in patients with COVID-19.
Source: Cardiology in Review - Category: Cardiology Tags: Feature Curbside Consult Source Type: research
Authors: Escalera-Antezana JP, Lizon-Ferrufino NF, Maldonado-Alanoca A, Alarcon-De-la-Vega G, Alvarado-Arnez LE, Balderrama-Saavedra MA, Bonilla-Aldana DK, Rodriguez-Morales AJ Abstract The present study is aimed to assess the risk factors for mortality in the first 107 rRT-PCR confirmed cases of SARS-CoV-2 infections in Bolivia. For this observational, retrospective and cross-sectional study, the epidemiological data records were collected from the Hospitals and the Ministry of Health of Bolivia, obtaining the clinical and epidemiological data of the COVID-19 cases that were laboratory-diagnosed during March 2-29,...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Drs Andrew Wilner and William Li discuss recent findings suggesting that many of the symptoms of SARS-CoV-2 -- stroke included -- may be due to underlying vascular pathology.Medscape Neurology
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Neurology & Neurosurgery Expert Interview Source Type: news
ConclusionIt is now time to end prejudice and adopt in this fight against Covid-19 alternative therapeutic techniques and practices that historically have proven effective in corresponding situations.
Source: Journal of Public Health - Category: Health Management Source Type: research
In late May, an otherwise relatively healthy New York City woman began having trouble speaking, and she felt weak on the right side of her body. But she could still walk and take care of herself, and with the coronavirus pandemic raging, visiting a hospital seemed too dangerous. The next day, her speech had gotten worse, and she could barely move the right side of her body. Her family called 911 and she was rushed to the hospital, where doctors determined she had suffered a stroke. By the time the woman left the hospital, she was no longer able to walk by herself, and was having difficulty speaking and understanding other...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Source Type: news
Publication date: Available online 4 June 2020Source: Obesity Research &Clinical PracticeAuthor(s): Diego Moriconi, Stefano Masi, Eleni Rebelos, Agostino Virdis, Maria Laura Manca, Salvatore De Marco, Stefano Taddei, Monica Nannipieri
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
Authors: Talevi D, Socci V, Carai M, Carnaghi G, Faleri S, Trebbi E, di Bernardo A, Capelli F, Pacitti F Abstract The coronavirus disease 2019 (CoViD-19) caused by the novel Coronavirus strain SARS-CoV-2 is currently a pandemic. On January 30, 2020, the World Health Organization declared that the CoViD-19 outbreak is a public health emergency of international concern. The virus has already had a direct impact on the physical health of million people, and besides, it is supposed to pose a mental health threat of great magnitude globally. This review aims at synthesizing mounting evidence concerning the immediate psy...
Source: Rivista di Psichiatria - Category: Psychiatry Tags: Riv Psichiatr Source Type: research
by Gertrud U. Rey Does a first infection with SARS-CoV-2 make a person immune to a second infection? This question is one of the prevailing issues in the current pandemic.  The relevant immune response is adaptive immunity, which initiates during a first exposure to a pathogen and protects from re-infection and disease upon a second […]
Source: virology blog - Category: Virology Authors: Tags: Gertrud Rey COVID-19 immunity neutralizing antibody pandemic SARS-CoV-2 T cells vaccine viral virology virus viruses Source Type: blogs
By RAGHAV GUPTA, MD “In seeking absolute truth, we aim at the unattainable and must be content with broken portions.” William Osler A colleague shared an experience with me about testing one of his patients for the novel coronavirus and it left me a bit puzzled.  An elderly gentleman with past medical history of severe COPD (chronic obstructive pulmonary disease) and heart failure came to the ER with shortness of breath, edema and fatigue.  Chest x-day suggested pulmonary edema.  He wanted to test him for SARS-CoV2 but hesitated.  Eventually he was able to order it ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
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