Interlink between insulin resistance and neurodegeneration with an update on current therapeutic approaches.
CONCLUSION: Research has shown that insulin insensitivity in T2DM leads to neurodegeneration through mechanisms involving a variety of extracellular, membrane receptor, and intracellular signaling pathway disruptions. Some therapeutics, such as intranasal administration of insulin and neuroactive substances have shown promise but face problems related to genetic background, accessibility to the brain, and invasiveness of the procedures.
PMID: 32418534 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Bhattamisra SK, Shin LY, Saad HIBM, Rao V, Candasamy M, Pandey M, Choudhury H Tags: CNS Neurol Disord Drug Targets Source Type: research
More News: Alzheimer's | Brain | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Diabetes Type 2 | Drugs & Pharmacology | Endocrinology | Genetics | Insulin | Learning | Neurology | Parkinson's Disease | Stem Cell Therapy | Stem Cells | Study | Universities & Medical Training