HAP1 Modulates Epileptic Seizures by Regulating GABAAR Function in Patients with Temporal Lobe Epilepsy and in the PTZ-Induced Epileptic Model.

This study provides evidence that hippocampal HAP1 is linked to GABAARs in evoking seizures and suggests that this mechanism is involved in epileptic seizures in the brain, representing a potential therapeutic target for epilepsy.
PMID: 32419121 [PubMed - as supplied by publisher]

Source: Neurochemical Research - May 16, 2020 Category: Neuroscience Authors: Li R, Wu B, He M, Zhang P, Zhang Q, Deng J, Yuan J, Chen Y Tags: Neurochem Res Source Type: research