Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery.

Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery.
Curr Top Med Chem. 2020 May 16;:
Authors: Sternberg A, McKee DL, Naujokat C
Abstract
Like other human pathogenic viruses, coronavirus SARS-CoV-2 employs sophisticated macromolecular machines for viral host cell entry, genome replication and protein processing. Such machinery encompasses SARS-CoV-2 envelope spike (S) glycoprotein required for host cell entry by binding to the ACE2 receptor, viral RNA-dependent RNA polymerase (RdRp) and 3-chymotrypsin-like main protease (3Clpro/Mpro). Under the pressure of the accelerating COVID-19 pandemic caused by the outbreak of SARSCoV- 2 in Wuhan, China in December 2019, novel and repurposed drugs were recently designed and identified for targeting the SARS-CoV-2 reproduction machinery, with the aim to limit spread of SARS-CoV-2 and morbidity and mortality of the COVID-19 pandemic.
PMID: 32416679 [PubMed - as supplied by publisher]

Source: Current Topics in Medicinal Chemistry - May 15, 2020 Category: Chemistry Authors: Sternberg A, McKee DL, Naujokat C Tags: Curr Top Med Chem Source Type: research