Bronchoalveolar Bile Acid and Inflammatory Markers to Identify High Risk Lung Transplant Recipients with Reflux and Microaspiration

Gastroesophageal reflux disease (GERD) is a risk factor for chronic lung allograft dysfunction (CLAD). The presence of bile acids —putative markers of gastric microaspiration—and inflammatory proteins in the bronchoalveolar lavage (BAL) has been associated with CLAD, but their relationship with GERD remains unclear. While GERD is thought to drive chronic microaspiration, selection of patients for anti-reflux surgery lacks precision. This multicenter study aimed to test the association of BAL bile acids with GERD, lung inflammation, allograft function, and anti-reflux surgery.

Source: The Journal of Heart and Lung Transplantation - May 18, 2020 Category: Transplant Surgery Authors: CY Kevin Zhang, Musawir Ahmed, Ella Huszti, Liran Levy, Sarah E Hunter, Kristen M Boonstra, Sajad Moshkelgosha, Andrew T Sage, Sassan Azad, Ricardo Zamel, Rasheed Ghany, Jonathan C Yeung, Oscar M Crespin, Courtney Frankel, Marie Budev, Pali Shah, John M R Tags: Original Clinical Science Source Type: research