Opposite regulation of piRNAs, rRNAs and miRNAs in the blood after subarachnoid hemorrhage

This report, although preliminary and largely proof-of-concept, is the first to describe alterations in sRNAs abundance levels in response to IA rupture in humans. The obtained results indicate novel mechanisms that may constitute another level of control of the inflammatory response.Key messagesA total of 542 sRNAs were differentially expressed after aneurysmal SAH comparing with controlspiRNAs and rRNAs were upregulated and miRNAs were downregulated after IA ruptureThe regulated sRNA showed an enrichment in the representation of some transcription factor binding sitespiRNAs, tRNAs, and rRNAs showed an overrepresentation for GR, RXRA, and ERALPHA binding sites
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research