Interaction of human immunodeficiency virus-1 and human immunodeficiency virus-2 capsid amino acid variants with human tripartite motif 5 & #945; protein SPRY domain and its association with pathogenesis

Conclusion: Polymorphisms in the capsid protein with both HIV-1- and HIV-2-monoinfected individuals showed the difference in the docking energy from the wild type. This is the first study which documents the difference in the usage of loop between the two HIV types for interaction with huTRIM5α. Variations in the capsid protein result in alteration in the binding to the restriction factor huTRIM5α.

Source: Indian Journal of Medical Microbiology - May 17, 2020 Category: Microbiology Authors: Veena Vadhini Ramalingam Suganya Subramanian G John Fletcher Priscilla Rupali George Varghese Susanne Pulimood Lakshmanan Jeyaseelan Balaji Nandagopal Gopalan Sridharan Rajesh Kannangai Source Type: research