The anti-tumorigenic effect of Ellagic acid in SKOV-3 ovarian cancer cells entails activation of autophagy-mediated by inhibiting Akt and activating AMPK.

In conclusion, EA can inhibit SKOV-3 growth, migration, and invasion by activating cytotoxic autophagy mediated by inhibition of mTORC1 and Akt and activation of AMPK.
PMID: 32415699 [PubMed - as supplied by publisher]

Source: Clinical and Experimental Pharmacology and Physiology - May 14, 2020 Category: Drugs & Pharmacology Authors: Elsaid FG, Alshehri MA, Shati AA, Al-Kahtani MA, Alsheri AS, Massoud EE, El-Kott AF, El-Mekkawy HI, Al-Ramlawy AM, Abdraboh ME Tags: Clin Exp Pharmacol Physiol Source Type: research