Deletion of c ‐Jun N‐terminal Kinase Enhances Senescence in Joint Tissues and Increases the Severity of Age‐Related Osteoarthritis in Mice

ConclusionJNK1 and JNK2 are not required for the development of OA in the mouse DMM model. Deletion ofJNK1 orJNK2 is associated with more severe age ‐related OA and increased cell senescence suggesting JNK may act as a negative regulator of senescence in the joint.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: FULL LENGTH Source Type: research