Effects of antipsychotic drugs on cardiovascular variability in participants with bipolar disorder

ConclusionsCurrent antipsychotic use (particularly second‐generation antipsychotics with high affinities for the D2S receptor) is associated with reduced autonomic‐mediated variability of the HR. The absence of an association with cumulative exposure suggests that the effects are acute in onset and may therefore relate more to altered autonomic function than structural cardiovascular abnormalities. Future studies should prospectively examine effects of these antipsychotics on autonomic function. Copyright © 2014 John Wiley & Sons, Ltd.

Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2013 Category: Psychiatry Authors: Jonathan R. Linder, Simrit K. Sodhi, William G. Haynes, Jess G. Fiedorowicz Tags: Research Article Source Type: research