H3PW12O40-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines.

H3PW12O40-Catalyzed Multicomponent Reaction for Efficient Synthesis of Highly Substituted Piperidines.
Comb Chem High Throughput Screen. 2013 Dec 29;
Authors: Khaksar S, Baghbanian SM, Barsan N
Abstract
A simple, diastereoselective, inexpensive, and efficient route for the synthesis of highly functionalized piperidines by the condensation of β-keto-esters, aromatic aldehydes and anilines using H3PW12O40 as a catalyst is described. The catalyst could be easily recovered after completion of the reaction and reused without a considerable change in its activity. Furthermore, in most cases the piperidine precipitates out of solution.
PMID: 24372051 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - December 29, 2013 Category: Chemistry Authors: Khaksar S, Baghbanian SM, Barsan N Tags: Comb Chem High Throughput Screen Source Type: research