Prevalence of globin gene modifiers encountered in fetuses during antenatal diagnosis of hemoglobinopathies.

CONCLUSION: Many fetuses had one or two gene modifiers. However, the impact of these on ameliorating the severity of the disease could not be evaluated as all the fetuses with β thalassemia major or sickle cell disease were terminated. Parents having heterozygous fetuses with α gene triplication should be followed up periodically after birth for better management of these babies.
PMID: 32412692 [PubMed - as supplied by publisher]

Source: International Journal of Laboratory Hematology - May 14, 2020 Category: Hematology Authors: Mehta P, Sawant P, Gorivale M, Nadkarni A, Colah R, Mukherjee MB Tags: Int J Lab Hematol Source Type: research