Evaluating Lean Liver Volume as a Potential Scaler for in vitro-in vivo Extrapolation of Drug Clearance in Obesity using the model drug antipyrine.
Conclusion The analysis indicates that LLV is potentially a more appropriate descriptor of functional liver size than LV, particularly in overweight individuals. Therefore, LLV has potential application in IVIVE of CL in obesity.
PMID: 32410559 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Sinha J, Duffull SB, Green B, Al-Sallami HS Tags: Curr Drug Metab Source Type: research
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