Overcoming Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutated Tumours.

Overcoming Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutated Tumours. J Oncol. 2020;2020:1079827 Authors: Paton EL, Turner JA, Schlaepfer IR Abstract Overactivation of the mitogen-activated protein kinase (MAPK) pathway is an important driver of many human cancers. First line, FDA-approved therapies targeting MAPK signalling, which include BRAF and MEK inhibitors, have variable success across cancers, and a significant number of patients quickly develop resistance. In recent years, a number of preclinical studies have reported alternative methods of overcoming resistance, which include promoting apoptosis, modulating autophagy, and targeting mitochondrial metabolism. This review summarizes mechanisms of resistance to approved MAPK-targeted therapies in BRAF-mutated cancers and discusses novel preclinical approaches to overcoming resistance. PMID: 32411231 [PubMed]
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research