N -arylated oxathiazinane heterocycles are convenient synthons for 1,3-amino ethers and 1,3-amino thioethers

AbstractThis communication describes a variety of nucleophilic ring openings ofN-arylated oxathiazinane heterocycles. We find that this reaction is compatible with phenoxides, naphthoxides, and thiolates and allows for the rapid assembly ofN-aryl-amino ethers andN-aryl-amino thioethers. Fourteen examples are shown and a mechanistic pathway is hypothesized.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
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