High mobility group AT-hook 2 promotes tumorigenicity of pancreatic cancer cells via upregulating ANLN.

This study uncovered the mechanism of HMGA2-mediated regulation of tumorigenicity in pancreatic cancer. We showed that HMGA2 was highly expressed in pancreatic cancer cells and correlated with poor prognosis. HMGA2 expression knockdown inhibited the tumorigenicity of pancreatic cancer cells. Conversely, overexpression of HMGA2 promoted tumorigenicity. Combination of ChIP-Seq, RNA-Seq and dual-luciferase reporter assays revealed HMGA2 could directly regulate ANLN expression. Furthermore, we found ANLN could mediate the HMGA2-induced effects on pancreatic cancer cells. The identification of the regulatory mechanism of HMGA2 and ANLN will provide insights into the progression for human pancreatic cancer. PMID: 32413362 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32413362?dopt=Abstract

Source: Experimental Cell Research - May 11, 2020 Category: Cytology Authors: Guo HH, Wang YZ, Zhang ZK, Li MZ, Tian XD, Yang YM Tags: Exp Cell Res Source Type: research