Type 2 Diabetes Mellitus and Osteoarthritis: the Role of Glucose Transporters

In conclusion, GLUT-1 composition in the plasma membrane of articular cell and chondrocyte increases glucose uptake in hyperglycemic conditions. This event leads to increased levels of inflammatory cytokines—such as IL-1β, TGF-β1, and MMP—oxidative stress, and AGEs. Therefore , these alterations induce the deleterious effects of glucotoxicity at the joint surface, which ultimately leads to OA.
Source: Clinical Reviews in Bone and Mineral Metabolism - Category: Internal Medicine Source Type: research