Detection of microsatellite instability from circulating tumor DNA by targeted deep sequencing

In this study, we developed an NGS-based algorithm, bMSISEA (blood MSI signature enrichment analysis), to detect MSI from blood samples. BMSISEA development involved 3 major steps. First, marker sites that can effectively distinguish MSI-high (MSI-H) from microsatellite stable (MSS) tumors were extracted.

Source: Journal of Molecular Diagnostics - May 14, 2020 Category: Pathology Authors: Zhenghao Cai, Zhenxin Wang, Chenglin Liu, Dongtao Shi, Dapeng Li, Minhua Zheng, Han Han-Zhang, Analyn Lizaso, Jianxing Xiang, Juan Lv, Wenjun Wu, Zhihong Zhang, Zhou Zhang, Fei Yuan, Songbing He, Jing Sun Tags: Technical Advance Source Type: research