Progression of disease within 2  years (POD24) is a clinically relevant endpoint to identify high-risk follicular lymphoma patients in real life

AbstractFollicular lymphoma (FL) is an indolent non-Hodgkin ’s lymphoma with heterogeneous outcomes. Progression or relapse of FL within 2 years (so-called POD24) after diagnosis is associated with a poor outcome for patients treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, prednisone) in clinical trials. POD24 needs further validation before it can be used as a relevant endpoint to assess treatment efficacy. In the present retrospective monocentric study, we investigated the predictive value of POD24 in a cohort of grade 1, 2, or 3a FL patients treated in our institution (Nantes Medical University, France) and registe red in our local database. We investigated the nature of treatment lines, patients’ outcomes, and the prognostic value of POD24. Between 2007 and 2016, 317 patients were included. After first-line therapy, 60 patients relapsed within 2 years (POD24-pos cohort), and 254 patients did not relapse wi thin 2 years (PO24-neg cohort). Thirty-three patients died, and 34 patients had an aggressive transformation. The median follow-up is 59.9 months (1.6–395.5). The median PFS is 59.9 months. Overall survival (OS) at 1 year, 3 years, and 5 years is 98.4% [97.0–99.8], 95.1% [92.6–97.6], and 92.5% [89.3–95.9], respectively. The 5-year OS was statistically lower for POD24-pos patients (82% [71.9–93.5]) than for POD24-neg patients (93.3% [88.98–97.8]) (p = 10−5). In multivariate analyses, transformation was predicti...
Source: Annals of Hematology - Category: Hematology Source Type: research