Expansion of circulating CD49b+LAG3+ type 1 regulatory T (Tr1) cells in human chronic graft-versus-host disease

Chronic graft-versus-host disease (cGVHD) remains the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (AHSCT). cGVHD is a multisystem, immune-mediated disease, characterized by tissue fibrosis and immune dysregulation of T and B-cells (MacDonald et al., 2017). The pathophysiology of cGVHD involves homeostatic abnormalities of thymus-derived regulatory T-cells (tTreg, described as CD4+FOXP3+IL-2Ra/CD25hiIL-7Ra/CD127low) including low tTreg numbers, decreased thymic export and increased susceptibility to Fas-mediated apoptosis (Matsuoka et al., 2010).

Source: Journal of Investigative Dermatology - May 15, 2020 Category: Dermatology Authors: N. Talvard-Balland, A. Sutra Del Galy, D. Michonneau, H. Le Buanec, F. Chasset, M. Robin, R. Peffault de Latour, A. Xhaard, F. Sicre de Fontbrune, N. Parquet, S. Duchez, V. Schiavon, M. Rybojad, A. Bergeron, M. Bagot, A. Bensussan, S. Caillat-Zucman, G. S Source Type: research