The Null Hypothesis of IFN- γ and Monocyte Function in Leishmaniasis.

The Null Hypothesis of IFN-γ and Monocyte Function in Leishmaniasis. Cell Host Microbe. 2020 May 13;27(5):683-684 Authors: Sacks DL Abstract The phagosomal pathogen Leishmania appears unaffected by deliberate changes in the early Th1/Th2 balance. In this issue, Carneiro et al. explain these paradoxical results by showing that manipulations affecting IFN-γ-mediated phagocyte activation are counteracted by effects on IFN-γ-dependent recruitment of CCR2+ monocytes permissive to parasite growth. PMID: 32407702 [PubMed - in process]
Source: Cell Host and Microbe - Category: Microbiology Authors: Tags: Cell Host Microbe Source Type: research