A directed network analysis of the cardiome identifies molecular pathways contributing to the development of HFpEF

The metabolic syndrome and associated comorbidities, like diabetes, hypertension and obesity, have been implicated in the development of heart failure with preserved ejection fraction (HFpEF). The molecular mechanisms underlying the development of HFpEF remain to be elucidated. We developed a cardiome-directed network analysis and applied this to high throughput cardiac RNA-sequencing data from a well-established rat model of HFpEF, the obese and hypertensive ZSF1 rat. With this novel system biology approach, we explored the mechanisms underlying HFpEF.

Source: Journal of Molecular and Cellular Cardiology - May 14, 2020 Category: Cytology Authors: Georg Summer, Annika R. Kuhn, Chantal Munts, Daniela Miranda-Silva, Adelino F. Leite-Moreira, Andr é P. Lourenço, Stephane Heymans, Inês Falcão-Pires, Marc van Bilsen Source Type: research