Novel Aminopyrazole Tagged Hydrazones as Anti-Tubercular Agents: Synthesis and Molecular Docking Studies.

CONCLUSION: Three compounds 5a5, 5b5 and 5b7 were found to be most potent among the series of compounds. Docking studies of compounds explained the presence of hydrogen bonding and π-π stacking interactions with InhA. Further synthesis of more such derivatives with optimized groups would produce compounds with more potent anti-tubercular activity.
PMID: 32407282 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - May 12, 2020 Category: Chemistry Authors: Padmini T, Bhikshapathi D, Suresh K, Kulkarni R, Kamal BR Tags: Med Chem Source Type: research