Expression of PD-L1, PD-L2, and IDO1 on tumor cells and density of CD8-positive tumor-infiltrating lymphocytes in early-stage lung adenocarcinoma according to histological subtype.
CONCLUSIONS: No cases in Groups A and B expressed PD-L1. The expression of immune-related factors, especially PD-L1 and IDO1, was significantly associated with Group C. This is the first report of the detailed examination of PD-L1, PD-L2, IDO1, and CD8 expression in lung adenocarcinoma subtypes with lepidic predominant components. Our results could help identify patients who would benefit from perioperative immunotherapy.
PMID: 32405745 [PubMed - as supplied by publisher]
Source: Clin Med Res - Category: Research Authors: Takada K, Toyokawa G, Kinoshita F, Jogo T, Kohashi K, Wakasu S, Ono Y, Tanaka K, Oba T, Osoegawa A, Tagawa T, Azuma K, Okamoto I, Shimokawa M, Oda Y, Mori M Tags: J Cancer Res Clin Oncol Source Type: research