A Sticky Wicket: Defining Molecular Functions for CD34 in Hematopoietic Cells

CD34, one of the best known and clinically important markers of hematopoietic progenitor cells, was first identified as a surface antigen expressed on the myeloblastic cell line KG-1a and a subpopulation (1-2%) of ‘normal’ human bone marrow (BM) containing most (∼95%) of the myeloid and erythroid lineage-committed progenitors [1]. We now know that CD34 marks resident progenitor cells for a diverse array of tissues including blood, stroma/fibro/adipocyte progenitors (FAPs), skeletal muscle, skin (keratoc ytes), endothelia and dermal epithelia (reviewed in ref [2]).

Source: Experimental Hematology - May 14, 2020 Category: Hematology Authors: Michael R. Hughes, Diana Canals Hernaez, Jessica Cait, Ido Refaeli, Bernard Lo, Calvin Roskelley, Kelly M. McNagny Tags: Review Source Type: research