Circulating protein biomarkers predict incident hypertensive heart failure independently of N ‐terminal pro‐B‐type natriuretic peptide levels

ConclusionsCardiomyocyte mRNA levels of GDF ‐15 and IL‐6 are consistently up‐regulated by stretch, and their circulating protein levels predict HF in hypertensive subjects independently of NT‐proBNP during long‐term follow‐up. Our results encourage further studies on lower blood pressure goals in hypertensive subjects with high GD F‐15 and IL‐6, and interventions targeted at stretch‐induced cardiomyocyte expressed biomarkers.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research