N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity
Drug resistance and chemotherapy-induced peripheral neuropathy continue to be significant problems in the successful treatment of acute lymphoblastic leukemia (ALL). 5,7-Dibromo-N-alkylisatins, a class of potent ...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Bryce Keenan, Rocio K. Finol-Urdaneta, Ashleigh Hope, John B. Bremner, Maria Kavallaris, Daniel Lucena-Agell, Mar ía Ángela Oliva, Jose Fernando Díaz and Kara L. Vine Tags: Primary research Source Type: research
More News: Acute Leukemia | Acute Lymphoblastic Leukemia | Brain | Cancer | Cancer & Oncology | Chemotherapy | Colchicine | Colcrys | Leukemia | Neurology | Peripheral Neuropathy