Brivaracetam prevents the over-expression of synaptic vesicle protein 2A and rescues the deficits of hippocampal Long-term potentiation in vivo in chronic temporal lobe epilepsy rats.

CONCLUSION: BRV treatment ameliorated the over-expression of SV2A in hippocampus and rescued the synaptic dysfunction in epileptic rats. These results identify the neuroprotective effect of BRV on TLE model. PMID: 32407277 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - Category: Neurology Authors: Tags: Curr Neurovasc Res Source Type: research