Effect of Nigella sativa and Fenugreek on the pharmacokinetics and pharmacodynamics of amlodipine, in hypertensive rats.

CONCLUSION: Results of pharmacodynamics and pharmacokinetics studies suggested that simultaneous administration of fenugreek or N. sativa with amlodipine improves the pharmacological response of amlodipine in hypertensive rats, though there was no remarkable change in pharmacokinetic parameters (Cmax, Kel, elimination t1/2, and AUC0-t,). PMID: 32407268 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32407268?dopt=Abstract

Source: Current Drug Metabolism - May 13, 2020 Category: Drugs & Pharmacology Authors: Alam MA, Bin Jardan YA, Raish M, Al-Mohizea AM, Ahad A, Al-Jenoobi FI Tags: Curr Drug Metab Source Type: research