Model-based Meta-analysis to Compare Primary Efficacy-endpoint, Efficacy-time Course, safety, and Tolerability of Opioids Used in the Management of Osteoarthritic Pain in Humans.

CONCLUSIONS: This MBMA provides clinically meaningful insights into the efficacy and safety profiles of oxycodone, oxymorphone, and tramadol. Resultantly, the presented framework analysis can have an impact in the clinic on drug development where it can guide: the optimization of doses of opioids required to manage osteoarthritic pain; the making of precise key decisions for the positioning of new drugs, and; the design more efficient trials. PMID: 32407270 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research