Mutational biosynthesis to generate novel analogs of nosiheptide featuring a fluorinated indolic acid moiety

Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00084A, PaperE Zhang, Heng Guo, Dandan Chen, Qian Yang, Yafei Fan, Yu Yin, Wengui Wang, Daijie Chen, Shoufeng Wang, Wen Liu The target product 6 ′-fluoro-nosiheptide (6′-F-NOS), along with 6′-fluoro-nosiheptide intermediate (NOS 6′-F-NOSint), was obtained by mutational biosynthesisvia 6 ′-fluoro-MIA feeding into mutant NosL. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research