Clonal tumor mutations in homologous recombination genes predict favorable clinical outcome in ovarian cancer treated with platinum-based chemotherapy.

CONCLUSIONS: HRR clonal mutations, but not subclonal mutations, were associated with improved survival, chemotherapy response, and genome instability compared with HRR wild-type.
PMID: 32402633 [PubMed - as supplied by publisher]

Source: Gynecologic Oncology - May 7, 2020 Category: Cancer & Oncology Authors: Luo S, Zhang Y, Yang Y, Zhu S, Liu W, Zhu J, Liang X, Jiang Z, Sun S, Hou X, Xiao Y, Li X Tags: Gynecol Oncol Source Type: research