LncRNA ILF3-AS1 mediated the occurrence of epilepsy through suppressing hippocampal miR-212 expression.

In this study, we showed that hippocampal and serum ILF3-AS1 levels are higher in TLE patients than in matched controls. Interleukin (IL)-1β and tumor necrosis factor (TNF)-α induced ILF3-AS1 expression in astrocytes, while ectopic expression of ILF3-AS1 enhanced IL-6 and TNF-α expression. Ectopic ILF3-AS1 in astrocytes also increased expression of MMP2, MMP3, MMP9 and MMP14, but suppressed expression of miR-212. Consistent with that finding, miR-212 levels were lower in the hippocampus and serum of TLE patients than their controls. This suggests that ILF3-AS1 promotes expression of inflammatory cytokines and MMPs by targeting miR-212 and that ILF3-AS1 plays a crucial role in the development of TLE. PMID: 32404536 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32404536?dopt=Abstract

Source: Aging - May 12, 2020 Category: Biomedical Science Authors: Cai X, Long L, Zeng C, Ni G, Meng Y, Guo Q, Chen Z, Li Z Tags: Aging (Albany NY) Source Type: research