2013 a record year for organ transplants - kidney association
Number of lung transplants at the Mater doubles to 32
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Renal ischemia-reperfusion injury (IRI) is an inherent process to kidney transplantation. The subsequent release of pro-inflammatory cytokines (e.g., IL-1 β, TNF-α, IL-6) may induce a systemic inflammatory response, resulting in pro-inflammatory cells recruitment and remote organ damage. Several studies have already documented dysfunction of the lung, heart, liver, and brain following renal IRI. The heme oxygenase-1 (HO-1), a stress-responsive enzym e endowed with cytoprotective, antiapoptotic, and immunomodulatory properties, protects kidney from renal IRI when pharmacology induced before ischemia.
Transplant candidates have advanced chronic disease, which often leads to muscular and respiratory impairment contributing to reduced quality of life and daily life activities, and these patients are therefore referred to physiotherapy service. Because of this, it is necessary to know the epidemiologic and functional profile for a better physiotherapeutic approach. Inpatients of kidney, liver, heart, lung and multivisceral transplantation programs were followed up for 1 year. A comparative analysis between groups was performed, taking into account hospital stay time and functional independence measure (FIM).
We have achieved tolerance of cardiac allografts in cynomolgus monkeys for the first time by using a mixed chimerism-based conditioning protocol and by co-transplanting a donor kidney. The mechanism by which a kidney confers tolerance upon a heart is unclear. To gain mechanistic insight and at the same time develop a clinically relevant tolerance protocol, we investigated whether a vascularized donor thymus could substitute for the donor kidney.
Lowering calcineurin inhibitor (CNI) exposure to avoid toxicity is desirable after solid organ transplantation although the risk of organ rejection is of concern after lung transplantation (LTx). The 4Everlung trial was designed to evaluate the benefit of early everolimus (EVR)-based quadruple low immunosuppressive (IS) regimen on kidney function (RF) after LTx
We previously developed a molecular diagnostic system for heart transplant biopsies, based on expression of rejection-associated transcripts derived in kidney transplants (J Heart Lung Transplant 36:1192, 2017). We now expanded this to 889 biopsies and examined the relationship to histology in 768 with histology assessments.
There is growing interest about the long-term lack of pulsatility during continuous flow left ventricular assist device (CFLVAD) on the renal function. Aim of this study is to evaluate the association between renal function and blood pressure during CFLVAD support.
Improved renal function following ventricular assist device (VAD) placement is seen in some, but not all VAD recipients. Failure to improve may indicate enduring renal injury. We hypothesized that VAD implantation results in improved renal function in the majority of pediatric patients with heart failure and that failure to improve would predict poor renal outcomes after heart transplantation (HT).
There is limited data to guide dual organ allocation in pts implanted with left ventricular assist device with bridge to transplant intention with chronic kidney disease (CKD). The goal of our study was to determine survival outcomes post transplant in LVAD patients with CKD who either received heart transplant alone (HTA) or heart kidney transplant( HKTx).
Kidney dysfunction has been shown to be a strong predictor for mortality. We investigated predictors of renal failure post Veno-Arterial Extracorporeal Membrane Circulation (VA ECMO).