Endothelial function in obesity and effects of bariatric and metabolic surgery.

Endothelial function in obesity and effects of bariatric and metabolic surgery. Expert Rev Cardiovasc Ther. 2020 May 13;: Authors: Sanches E, Topal B, Proczko M, Stepaniak PS, Severin R, Philips SA, Sabbahi A, Pujol Rafols J, Pouwels S Abstract IntroductionDue to the lifestyle changes and the on-going urbanization waves there is obesity pandemic. The visceral fatty tissue of patients with obesity, in comparison with subcutaneous fat, has more gene expression related to inflammation, oxidative stress, cytokine production and angiogenesis. The abovementioned leads to a decrease in arteriolar function and also an impaired endothelial vasodilatation and eventually endothelial dysfunction.Areas CoveredThis review aims to provide an overview of the pathophysiology of obesity and endothelial dysfunction and the effects after bariatric and metabolic surgery and the consequences of surgery for the endothelial function. In this review we focussed and searched for literature in Pubmed and The Cochrane library, (from the earliest date of each database until February 2020) regarding endothelial function, obesity and effects of bariatric and metabolic surgery.Expert opinionWithin cardiovascular research, the endothelium and its function have a prominent role and it is the responsibility of the researchers to unravel the pathophysiological mechanisms and potential new targets for treatment of cardiovascular diseases. PMID: 32400225 [PubMed ...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research