Asymmetric N-Aminoalkylation of 3-Substituted Indoles by N- protected N,O-acetals: An Access to Chiral Propargyl Aminals

Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00795A, CommunicationJunxian Yang, Zeyuan He, Liang Hong, Wangsheng Sun, Rui Wang A direct enantioselective N1 aminoalkylation of 3-substituted indoles is efficiently catalyzed by a phosphoric acid catalyst under mild conditions to afford diverse enantioenriched propargyl aminals. The strategy could be applied... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research