New strategies for safe cancer therapy using electrospun nanofibers: A short review.

New strategies for safe cancer therapy using electrospun nanofibers: A short review.
Mini Rev Med Chem. 2020 May 13;:
Authors: Doostmohammadi M, Forootanfar H, Ramakrishna S
Abstract
Electrospun nanofibers regarding to their special features including high drug loading capacity, high surface to volume area, flexibility and ease of production and operation are of great interest for being used in tissue engineering and drug delivery approaches. In this context several studies have been done for production of biodegradable and biocompatible scaffolds containing different anticancer agents for fighting with solid tumors. Surprisingly these scaffolds are able to deliver different combinations of drugs and agents such as nanoparticles and release them in time dependent manner. Here in this review, we summarize the principles of electrospinning and their uses in entrapment of drugs and anti-proliferative agents suitable for cancer therapy. The latest studies performed on treating cancer using electrospinning are mentioned and their advantages and disadvantages over conventional treatment methods are discussed.
PMID: 32400330 [PubMed - as supplied by publisher]

Source: Mini Reviews in Medicinal Chemistry - May 12, 2020 Category: Chemistry Authors: Doostmohammadi M, Forootanfar H, Ramakrishna S Tags: Mini Rev Med Chem Source Type: research