Adherence to inhaled corticosteroids and clinical outcomes in mepolizumab therapy for severe asthma

We examined ICS adherence and clinical outcomes in OCS-dependent severe eosinophilic asthma patients who completed 1 year of mepolizumab therapy. The ICS medicines possession ratio (MPR) was calculated (the number of doses of ICS issued on prescription/expected number) for the year before and the year after biologic initiation. Good adherence was defined as MPR>0.75, intermediate 0.74–0.51 and poor
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma Source Type: research

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Authors: Vultaggio A, Nencini F, Bormioli S, Vivarelli E, Dies L, Rossi O, Parronchi P, Maggi E, Matucci A Abstract Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by multisystemic manifestations including asthma. Mepolizumab (300 mg/4 weeks) has recently been approved for EGPA. However, real-life data are scarce and report experiences with high doses of mepolizumab intravenously administered (750 mg/4 weeks). The aim of our study was to investigate in a real-life setting whether mepolizumab in EGPA patients at low doses would enable us 1) to control asthma symptoms, 2) to obtain ...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
This study aimed to determine the impact of coexisting COPD on long-term mortality in patients with CS-dependent asthma. METHODS: A retrospective cohort of patients with CS-dependent asthma aged 40 years or older was established using records from the Korean National Health Insurance Service database for 2005 to 2015. We classified the subjects into 2 groups according to the presence of COPD and evaluated the hazard ratio (HR) for all-cause mortality in patients with COPD relative to those without COPD. RESULTS: Of 8,021 patients with CS-dependent asthma, 3,121 (38.9%) had COPD. All-cause mortality was significantl...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
We report this consensus to support allergists and clinical immunologists to make optimal decisions under the urgent situation in Asia. PMID: 32638559 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
AbstractPurpose of ReviewEustachian tube dysfunction (ETD) presents with symptoms of aural fullness and pressure, muffled hearing, tinnitus, and otalgia. When severe, it can lead to many common ear disorders such as otitis media with effusion, tympanic membrane retraction/perforation, and cholesteatoma. These diseases are prevalent in both the pediatric and adult population and significantly impact quality of life. The pathophysiology of ETD in the absence of an obstructive lesion has long been debated but is thought to be related to functional obstruction (i.e., inefficient tensor veli palatini muscle) and/or nasal cavity...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Currently a combination of intranasal corticosteroid (INCS) plus oral H1antihistamines (OAH) or intranasal H1-antihistamines (INAH) therapy is frequently used in the treatment of allergic rhinitis (AR). The superiority of the two combined treatments needs to be further examined.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
CONCLUSION: Intranasal H1-antihistamines have an add-on effect on intranasal corticosteroids and intranasal H1-antihistamines plus intranasal corticosteroid is superior to oral H1-antihistamines plus intranasal corticosteroid, in improving nasal symptoms for AR patients. PMID: 32650045 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
Abstract BACKGROUND: Fraction exhaled nitric oxide (FeNO) is a non-invasive biomarker of type-2 asthma that can predict response to inhaled corticosteroid(ICS) therapy. Little is known regarding the magnitude of FeNO reduction following an oral corticosteroid(OCS) course and less is known whether there are differential responses based on race in children with mild-to-moderate asthma. OBJECTIVE: To assess the effect of a short course of OCS on FeNO in asthmatic children and to determine if the effect is influenced by race. METHODS: Children presenting with an acute asthma exacerbation, who had a FeNO meas...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
Source: Journal of Asthma and Allergy - Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Idiopathic nonhistaminergic acquired angioedema (InH-AAE) is a rare disease characterized by submucosal swelling without concomitant urticaria and poor response to antihistamines and corticosteroids.1 Compared with other forms of hereditary and acquired angioedema, InH-AAE seems to have a predilection for facial and tongue swelling, and is often difficult to diagnose as patients have normal laboratory values and no family history.1 To our knowledge, there have been no publications to date describing idiopathic nonhistaminergic angioedema as a complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infe...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Fraction exhaled nitric oxide (FeNO) is a non-invasive biomarker of type-2 asthma that can predict response to inhaled corticosteroid(ICS) therapy. Little is known regarding the magnitude of FeNO reduction following an oral corticosteroid(OCS) course and less is known whether there are differential responses based on race in children with mild-to-moderate asthma.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
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