Patient-Reported Outcomes, Physician-Reported Toxicities, and Treatment Outcomes in a Modern Cohort of Patients with Sinonasal Cancer Treated Using Proton Beam Therapy

Sinonasal malignancies are an uncommon subgroup of head and neck cancers that are difficult to treat due to disease heterogeneity, intricate anatomy, and lack of randomized evidence to guide treatment decisions.1,2 As locally advanced disease is common at time of presentation, patients require multidisciplinary evaluation and management using a combination of surgery, chemotherapy, and radiotherapy.3 Historically, sinonasal cancer outcomes have demonstrated minimal improvement over treatment eras, from the 1970s to the 2000s, with approximate three-year local control (LC), disease-free survival (DFS), and overall survival (OS) rates of 65%, 55%, and 70%, respectively.

Source: Radiotherapy and Oncology - May 13, 2020 Category: Radiology Authors: Dario Pasalic, Ethan B. Ludmir, Pamela K. Allen, Nikhil G. Thaker, Bhavana V. Chapman, Ehab Y. Hanna, Shirley Y. Su, Renata Ferrarotto, Bonnie S. Glisson, Jay P. Reddy, G. Brandon Gunn, Clifton D. Fuller, Jack Phan, David I. Rosenthal, William H. Morrison Tags: Original Article Source Type: research